Table 1.

TMS mapping results. Mean ± standard deviation for the different TMS parameters assessed before and after one hour of synchronized movements of the right thumb and shoulder under different conditions

	Single dosage (n= 8)
	Placebo		Memantine
	Before training	After training	Before training	After training
x coordinate COG (cm)	1.58 ± 0.61	1.59 ± 0.67	1.43 ± 0.72	1.58 ± 0.62
y coordinate COG (cm)	-4.82 ± 0.44	-4.74 ± 0.41	-4.98 ± 0.56	-4.97 ± 0.65
Motor threshold (%)	34.6 ± 3.0	34.1 ± 2.7	35.0 ± 1.7	34.4 ± 1.9
Area (cm2)	14.6 ± 4.4	13.8 ± 2.8	15.5 ± 5.2	16.1 ± 2.8
Sum of amplitudes (μV)	1584.6 ± 999.6	1412.0 ± 797.8	2022.4 ± 1193.6	1733.0 ± 756.6
Number of "hotspots"	3.4 ± 2.4	2.7 ± 2.6	4.2 ± 2.8	3.4 ± 2.3
Mean amplitude (μV)	116.1 ± 94.9	100.4 ± 49.9	161.9 ± 180.6	111.4 ± 53.9
	Ascending dosage over 8 days (n = 7)
	Placebo		Memantine
	Before training	After training	Before training	After training
x coordinate COG (cm)	1.21 ± 0.60	1.38 ± 0.59	1.49 ± 0.64	1.53 ± 0.66
y coordinate COG (cm)	-5.46 ± 0.69	-5.34 ± 0.61	-5.36 ± 0.50	-5.44 ± 0.59
Motor threshold (%)	40.6 ± 7.1	39.7 ± 6.5	41.3 ± 7.3	40.9 ± 7.0
Area (cm2)	16.6 ± 3.8	15.7 ± 3.6	15.9 ± 3.6	16.3 ± 3.7
Sum of amplitudes (μV)	1901.6 ± 1515.8	1535.1 ± 939.3	1744.4 ± 1086.0	1726.7 ± 808.6
Number of "hotspots"	4.4 ± 3.5	3.6 ± 2.6	3.9 ± 3.1	3.6 ± 2.8
Mean amplitude (μV)	120.5 ± 95.4	104.3 ± 65.0	107.2 ± 52.7	107.6 ± 45.2
	Low dosage (10 mg/d) over 8 days (n = 5)
			Memantine
			Before training	After training
x coordinate COG (cm)			0.80 ± 0.46	0.62 ± 0.71
y coordinate COG (cm)			-5.12 ± 0.46	-5.20 ± 0.53
Motor threshold (%)			38.4 ± 8.3	38.8 ± 12.1
Area (cm2)			12.0 ± 4.1	14.6 ± 4.0
Sum of amplitudes (μV)			1852.2 ± 2169.4	1984.6 ± 1686.1
Number of "hotspots"			3.8 ± 3.8	4.0 ± 4.3
Mean amplitude (μV)			131.2 ± 106.1	122.0 ± 92.5