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(A) Epidermotropic theory: Paget cells originate in the underlying adenocarcinoma, and neoplastic epithelial cells migrate through the ductal system of the breast to reach the nipple epidermis. (B) Intraepidermal transformation theory: Paget cells originate through degeneration or in situ transformation of epidermal keratinocytes in the nipple-areola complex.
MPD: mammary Paget’s disease
Image made using biorender.com
Image Credit: Humza F. Siddiqui
