Table 3.

The World Health Organization recommends treatment regimens for drug-resistant leprosy.

Resistance type	Drug therapy
	First 6 months (daily)	Next 18 months (daily)
Rifampicin resistance	Ofloxacin 400 mg* + minocycline 100 mg + clofazimine 50 mg	Ofloxacin 400 mg* OR minocycline 100 mg + clofazimine 50 mg
	Ofloxacin 400 mg* + clarithromycin 500 mg + clofazimine 50 mg	Ofloxacin 400 mg + clofazimine 50 mg
Rifampicin and ofloxacin resistance	Clarithromycin 500 mg + minocycline 100 mg + clofazimine 50 mg	Clarithromycin 500 mg OR minocycline 100 mg + clofazimine 50 mg

^* Ofloxacin 400 mg can be replaced with levofloxacin 500 mg or moxifloxacin 400 mg.