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. 2005 Jan 7;385(Pt 2):433–443. doi: 10.1042/BJ20041024

Figure 2. Phylogenetic footprinting.

Figure 2

(A) Alignment of the proximal human (SMN) and mouse (Smn) promoters; regions of conserved sequence identity are underlined (CR1–CR4). Vertical bars and boxes annotate sequence identity and putative cis-elements respectively. The IL-6 site corresponds to the NF-IL6 response element. (B) The human proximal promoter sequence and the mutations introduced by site-directed mutagenesis are shown above the putative Sp1, AhR, Ets and IL-6 cis-elements. The arrow ↱ corresponds to the +1 TIS.