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. 2024 Jun 17;52(15):9210–9229. doi: 10.1093/nar/gkae505

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Genomic location does not influence the effect of PlaB on miRNA biogenesis. (A) Effects of PlaB on biogenesis of the 25 most highly expressed miRNAs. miRNAs are grouped according to genomic location. For each genomic location, miRNAs are ordered from highest to lowest expression. (B) Comparison of the effect of PlaB on biogenesis of all miRNAs in the filtered dataset from exonic or intronic locations. (C) As panel (B), except that miRNAs were grouped by lncRNA or protein-coding gene location. (D) As panel (B), except that miRNAs were grouped by the presence or absence of the CNNC, basal UG or apical UGU cis-acting motifs. (E) Scatterplot showing effect of PlaB on miRNA biogenesis relative to distance from TSS. For all data, the effect of PlaB was determined by T>C conversion rate in (PlaB − Control)/(DMSO − Control) based on mean values of four independent experiments for each miRNA. Box plots in panels (B)–(D) show median as a line, with 10th and 90th centiles forming the box, and outliers shown as individual data points. n.s., not significant.