Figure 7.

Altered codon dwell times in RPL39l KO relative to WT clones. (A) Change in codon dwell time in the RPL39L KO clones relative to WT, conditioned on the presence of leucine at position +31 in the NPET. For each amino acid the 4 columns correspond to the 4 independent clones, shown always in the same order: 1_17, 1_20, 2_9 and 2_11. (B) Location-dependent P-values in the Mann–Whitney U test comparing the fractions of amino acids in coiled-coil structures within 100 length bins in presumed Rpl39l (39) targets and non-target proteins (4720). (C) Expression level (TPM) of mRNAs encoding proteins with coiled-coil domains that are destabilized in the RPL39L KO clones. Shown are values obtained by scRNA-seq of various cell types in the Human Protein Atlas. The gene names are indicated at the top of each panel and the cell types are labeled on the x-axis.