Table 2.
The parameter estimates of final population pharmacokinetic model
| Parameter (unit) | Model estimate | Bootstrap results | |||||
| Estimate | RSE% | 95% CI* | Iiv (CV%) | η-shrinkage | Median | 95% CI† | |
| Vc (L) | 16.378 | 2.283 | 15.641 to 17.116 | 89.853 | 0.466 | 16.460 | 5.110 to 32.423 |
| Vp (L) | 10.904 | 3.951 | 10.054 to 11.754 | 8.319 | 0.450 | 12.505 | 8.434 to 73.773 |
| Q (L/h) | 7.645 | 4.086 | 7.029 to 8.261 | 24.453 | 0.249 | 7.539 | 2.919 to 17.858 |
| CL (L/h) | 11.357 | 3.024 | 10.679 to 12.035 | 35.748 | 0.456 | 11.367 | 9.248 to 14.227 |
| fCrCl | 0.473 | 5.181 | 0.425 to 0.521 | to | to | 0.468 | 0.375 to 0.590 |
| Residual error (proportional error, CV%) | |||||||
| CV% | 30.370 | 5.126 | 27.298 to 33.442 | to | to | 30.537 | 23.936 to 38.133 |
fCrCl is the coefficient representing the relationship between CrCl and CL (Eq. 8), and CL increases as CrCl increases. The IIV decreased from 38.562% (base model) to 35.748% (final model).
*The range was calculated by the equation estimate ±1.96 SE.
†2.5th and 97.5th percentile of the ranked bootstrap parameter estimates.