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. 2024 May 9;73(9):1543–1553. doi: 10.1136/gutjnl-2024-332033

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Liver repair after IR injury is impaired when hb-egf is deleted in hepatic macrophages. Male Hb-egf^fl/flClec4f-Cre^+/-mice and WT littermates (Male Hb-egf^fl/flClec4f-Cre^-/-) were subjected to hepatic IR surgery. After 24h, Hb-egf^fl/flClec4f-Cre^+/- mice were divided into two groups and injected (i.p.) with PBS or IL-4c (n=6/group). (A) Serum ALT levels at 6h after IR surgery. (B, C) Liver necrosis (N, outlined areas) was evaluated and quantified on day 7 after IR surgery. (D) Liver pathology was assessed by using the Suzuki’s scoring system on day 7 after IR surgery. (E, F) Proliferative hepatocytes were stained for Ki67 and quantified on day 3 after IR surgery (n=4/group). (G, H) PCNA protein expression was detected by Western blotting and quantified. (I, J) p-EGFR and t-EGFR protein expression levels were detected by Western blotting and quantified. Two-tailed unpaired Student’s t-test with Welch’s correction was performed in A, F, H and J. One-way ANOVA was performed in C and D.