Table 4.

GRADE evidence profile for PICO 7

Certainty assessment							№ of patients		Effect		Certainty	Importance
№ of studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Direct EVT	IVT+	Relative (95% CI)	Absolute (95% CI)
mRS 0–3 at 90 days observational
2	Non-randomized studies	Serious*	Not serious	Not serious	Serious†	None	154/436 (35.3%)	81/196 (41.3%)	OR 0.75 (0.50 to 1.12)	68 fewer per 1000 (from 153 fewer to 28 more)	⨁⨁◯◯Low	CRITICAL
mRS 0–2 at 90 days observational
5	Non-randomized studies	Serious‡	Not serious	Not serious	Serious†	None	272/682 (39.9%)	161/360 (44.7%)	OR 0.70 (0.48 to 1.05)	86 fewer per 1000 (from 168 fewer to 12 more)	⨁⨁◯◯Low	CRITICAL
shift mRS 90 days observational
3	Non-randomized studies	Serious*	Not serious	Not serious	Serious†	None			OR 0.58 (0.37 to 0.90)	One fewer per 1000 (from 1 fewer to 0 fewer)	⨁⨁◯◯Low	CRITICAL
TICI 2B/3 90 days observational
4	Non-randomized studies	Serious*	Not serious	Not serious	Serious†	None	604/754 (80.1%)	308/371 (83.0%)	OR 0.89 (0.40 to 1.96)	17 fewer per 1000 (from 169 fewer to 75 more)	⨁⨁◯◯Low	CRITICAL
sICH observational
4	Non-randomized studies	Serious*	Not serious	Not serious	Serious†	None	41/741 (5.5%)	18/363 (5.0%)	OR 1.20 (0.35 to 4.07)	Nine more per 1000 (from 32 fewer to 126 more)	⨁⨁◯◯Low	CRITICAL

*Serious risk of bias due to serious confounding reported in both studies implemented for this outcome according to ROBINS-I tool for observational studies.

† Serious imprecision due to low optimal information size. The total number of patients included is less than the number of patients generated by a conventional size sample calculation for a single adequately powered clinical trial.

‡Serious risk of bias due to serious confounding reported in studies implemented for this outcome according to ROBINS-I tool for observational studies.

CI, confidence interval; EVT, give details; mRS, modified Rankin Scale; OR, give details; OR, odds ratio; sICH, give details; TICI, give details.