Skip to main content
. 2024 Jul 17;38(9):2051–2058. doi: 10.1038/s41375-024-02346-z

Fig. 1. Morphological changes of platelets and red blood cells (RBC) in 135 patients with myeloproliferative neoplasms (MPN) and 83 healthy controls by immunofluorescence microscopy on the blood smear.

Fig. 1

A Representative picture of aggregates of non-muscular myosin IIA (NMMIIA) in RBC of a MPN patient in comparison to a healthy control. P indicates platelets, arrows indicate the RBC aggregates. B Reduced expression of the alpha granule markers von Willebrand factor (vWF), P-selectin (P-sel) and thrombospondin 1 (TSP1) in a MPN patient compared to a healthy control. C Left. Schematic representation of the spectrum of morphologic alterations found in patients and controls, and their prevalence. Right. Allele burden of mutations in JAK2, CALR or MPL gene within MPN patients grouped according to the found morphologic change(s), which are designated by capital letters at the stacked bar graph. Boxes represent the interquartile range, bars within the boxes designate the median values, and whiskers extend to the range of data (minimum and maximum).