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. 2024 May 15;72(4):776–787. doi: 10.1007/s12026-024-09484-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Treatment effect on keyhole limpet haemocyanin (KLH) challenge responses. Basal flow (AU) (a), flare (AU) (b) and erythema (AU) (c) of the skin over time after intradermal KLH skin challenge, measured by laser speckle contrast imaging (LSCI) and multispectral imaging. KLH-specific IgG antibodies (d) and KLH-specific IgM antibodies (e) over time during KLH immunizations, expressed as % compared to baseline. Participants were immunized at day 8, 22 and 36. Mean (standard deviation). AU arbitrary unit. p-values refer to the following contrasts: upper p-value EDP1815 overall vs placebo; EC1 EDP1815-EC1 vs placebo; EC2 EDP1815-EC2 vs placebo