Table 1.
Baseline characteristics
| EDP1815-EC1 (N = 13) | EDP1815-EC2 (N = 13) | Placebo (N = 12) | |
|---|---|---|---|
| Sex (N male, %) | 6, 46.2% | 7, 53.8% | 10, 83.3% |
| Age, years (mean ± SD) | 25.5 (5.2) | 26.5 (7.1) | 27.4 (5.9) |
| BMI, kg/m2 (mean ± SD) | 24.32 (2.61) | 22.98 (2.45) | 23.75 (3.36) |
| Body weight, kg (mean ± SD) | 75.64 (14.25) | 73.18 (10.23) | 78.13 (15.30) |
| Systolic blood pressure, mmHg (mean ± SD) | 117 (9.3) | 112 (9.3) | 125 (11.1) |
| Diastolic blood pressure, mmHg (mean ± SD) | 68 (6.9) | 68 (6.7) | 71 (7.4) |
| Heart rate, beats per minute (mean ± SD) | 57 (6.2) | 57 (7.7) | 60 (8.7) |
| CRP, mg/L (mean ± SD) | 1.69 (1.46) | 1.29 (1.61) | 1.35 (1.81) |
| AST, U/L (mean ± SD) | 24 (4.7) | 21 (7.9) | 21 (6.7) |
| ALT, U/L (mean ± SD) | 24 (11.0) | 21 (11.1) | 24 (12.6) |
| GGT, U/L (mean ± SD) | 16 (7.6) | 15 (7.5) | 17 (10.9) |
| Fasted glucose, mmol/L (mean ± SD) | 4.6 (0.23) | 4.8 (0.38) | 4.9 (0.37) |
| Sodium, mmol/L (mean ± SD) | 139 (1.8) | 140 (2.1) | 140 (2.2) |
| Potassium, mmol/L (mean ± SD) | 4.3 (0.23) | 4.5 (0.48) | 4.4 (0.37) |
| Triglycerides, mmol/L (mean ± SD) | 0.82 (0.27) | 1.09 (1.02) | 1.04 (0.61) |
BMI body mass index, CRP C-reactive protein, AST aspartate transaminase, ALT alanine transaminase, GGT gamma-glutamyl transferase, SD standard deviation