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. 2024 Aug 26;15(8):621. doi: 10.1038/s41419-024-06996-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A mRNA expression of SMARCA4 in the GSE13159 dataset (B-ALL, n = 576; Control, n = 74). Comparative analysis of single-cell sequencing data from the GSE132509 and GSE154109 datasets, with orange representing immune cells, blue representing malignant cells, and green representing stromal cells. B Images of BRG1 expression level analysis in immune cells, malignant cells and mesenchymal cells. National Comprehensive Cancer Network (NCCN) Guidelines version 1.2023-defined risk groups were used to divide tumour samples in the TCGA dataset for SMARCA4 gene expression (logPRKM). C Scatter-bar plot of mRNA expression of BRG1 in TCGA adult B-ALL dataset aged >18 years (6570 days). D Kaplan–Meier survival curve in TARGET dataset. E The mRNA expression of BRG1 was analysed via qRT-PCR in healthy control (n = 35) and patients with B-ALL (n = 31). F The expression of BRG1 was detected by immunoblotting in healthy control (#H1-#H11) and patients with B-ALL (#P1-#P11). G Representative images of ICC staining of BRG1 in B-ALL samples (#P1-#P3) and healthy control samples (#H1-#H3) (scale bar = 50 μm). (*P < 0.05; ***P < 0.001).