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. 2024 Aug 26;14:19748. doi: 10.1038/s41598-024-70642-w

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© The Author(s) 2024

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Fig. 4 — Protein sequence comparison and homology modelling of SIRT1. (A) Partial amino acid sequence alignment of Hoplostethus and other fish, vertebrate and invertebrate species; position p.412 is highlighted. This position is also represented in a protein model of SIRT1 from (B) H. mediterraneus; (C) H. atlanticus; and (D) a human model with interaction with resveratrol⁸⁴. The dashed blue lines indicate H-bonds, whereas the dashed purple line indicates steric clashes.