Table 4. Output data of 2³ factorial analyses of Bac-loaded NISNV formulae .

Responses	R2	Adjusted R2	Predicted R2	Adequate precision	Significant factors
EE (%)	0.92	0.90	0.86	20.83	X1, X2, X3
PS (nm)	0.87	0.84	0.78	14.87	X1, X2, X3
Response		EE (%)		PS (nm)
Observed values		84.53		174.64
Predicted values		88.14		169.67

X₁: surfactant type; X₂: surfactant/cholesterol ratio; X₃: sonication time (min); EE: entrapment efficiency; PS: particle size.