Table 3.
Oxidative stress and antioxidant activity biomarkers concentrations in EXPERIVA study participants by age and pregnancy trimester.
| Biomarker | Ages 18–29 (n = 29) | Ages 30–40 (n = 56) | First trimester (n = 15) | Second trimester (n = 39) | Third trimester (n = 31) |
|---|---|---|---|---|---|
| Median (min; max) | Median (min; max) | Median (min; max) | Median (min; max) | Median (min; max) | |
| Oxidative stress biomarkers | |||||
| MDA (μM) | 21.37 (2.82; 42.70) | 25.40 (2.04; 51.20) | 24.11 (7.20; 47.84) | 25.58 (4.74; 51.20) | 21.92 (2.04; 42.70) |
| 8-IP (µg/l) | 0.10 (0.01; 0.64) | 0.07 (0.01; 1.03) | 0.07 (0.01; 0.42) | 0.07 (0.01; 1.03) | 0.10 (0.01; 0.66) |
| 8-OHdG (ng/ml) | 68.38 (23.47; 150.44) | 79.27 (21.31; 173.49) | 82.79 (21.31; 128.77) | 67.84 (24.31; 173.49) | 90.29 (23.47; 155.51) |
| Antioxidant activity biomarkers | |||||
| TAC (mMTrolox) | 2.91 (0.50; 5.14) | 2.92 (0.26; 5.66) | 2.30 (0.50; 3.61) | 3.03 (0.26; 5.31) | 2.98 (0.65; 5.66) |
| SOD (% inhibition) | 52.66 (1.54; 99.00) | 31.94 (3.03; 99.00) | 51.51 (3.03; 99.00) | 32.64 (1.54; 99.00) | 37.50 (5.00; 99.00) |
| CAT (mU/ml) | 0.04 (0.001; 0.18) | 0.03 (0.001; 0.19) | 0.04 (0.001; 0.17) | 0.03 (0.0001; 0.19) | 0.04 (0.001; 0.18) |
| GST (mU/min/ml) | 95.82 (30.29; 217.00) | 121.36 (22.70; 246.42) | 117.54 (22.70; 246.42) | 98.09 (30.29; 224.36) | 121.34 (30.29; 241.52) |
| aMT6s (ng/ml) | 226.09 (50.00; 1700.77) | 233.62 (23.59; 2082.78) | 279.19 (95.91; 1154.23) | 231.65 (32.48; 1700.77) | 193.43 (23.60; 2082.77) |