Table 5.

Associations (standardized betas) between exposure metrics and log10-transformed oxidative stress and antioxidant biomarkers concentrations in the EXPERIVA study.

Exposure metrics	TAC	SOD	GST	CAT	aMT6s	MDA	8-OHdG	8-IP
All—ID2W no buffer	−0.020	−0.134	−0.004	0.144	−0.128	0.092	−0.237*	−0.024
All—ID2W 10 km	−0.031	−0.150	−0.020	0.172	−0.142	0.093	−0.236*	−0.014
All—ID2W 5 km	−0.036	−0.153	−0.023	0.182✝	−0.144	0.089	−0.242*	−0.008
All—Density 10 km	0.036	−0.118	0.038	−0.032	−0.049	0.080	−0.103	−0.086
All—Density 5 km	0.018	−0.148	−0.007	0.071	−0.119	0.068	−0.226✝	−0.080
UOG—ID2W no buffer	−0.002	−0.228*	−0.017	0.115	−0.146	0.030	−0.281*	−0.090
UOG—ID2W 10 km	−0.0003	−0.224*	−0.028	0.142	−0.163	0.038	−0.290*	−0.074
UOG—ID2W 5 km	0.002	−0.218*	−0.031	0.152	−0.173✝	0.043	−0.299*	−0.066
UOG—Density 10 km	−0.008	−0.196✝	0.034	−0.052	0.006	0.003	−0.075	−0.114
UOG—Density 5 km	−0.007	−0.184	−0.013	0.063	−0.099	0.019	−0.205✝	−0.090
UOG—PAD no buffer	0.020	−0.049	0.000	−0.138	0.134	0.022	0.099	−0.060
UOG—PAD 10 km	0.074	−0.015	0.015	−0.097	0.121	0.078	0.107	0.003
UOG—PAD 5 km	0.106	−0.030	0.049	−0.095	0.071	0.077	0.078	−0.011
UOG—DRILL no buffer	−0.024	−0.034	−0.048	−0.134	0.153	0.040	0.062	−0.072
UOG—DRILL 10 km	0.026	0.008	−0.027	−0.097	0.137	0.093	0.083	−0.009
UOG—DRILL 5 km	0.072	−0.008	0.019	−0.097	0.089	0.092	0.047	−0.031
UOG—STIM no buffer	−0.052	−0.035	−0.031	−0.076	0.135	0.084	0.044	−0.074
UOG—STIM 10 km	−0.034	−0.013	−0.021	−0.055	0.113	0.115	0.062	−0.027
UOG—STIM 5 km	−0.025	−0.026	0.008	−0.041	0.078	0.119	0.043	−0.026
UOG—PROD no buffer	0.079	−0.142	0.070	−0.113	0.025	−0.115	0.041	−0.053
UOG—PROD 10 km	0.094	−0.133	0.060	−0.087	0.013	−0.110	0.049	−0.023
UOG—PROD 5 km	0.094	−0.119	0.062	−0.072	−0.013	−0.098	0.041	0.003
Conv—ID2W no buffer	−0.035	0.085	0.018	0.104	−0.028	0.132	−0.033	0.090
Conv—ID2W 10 km	−0.066	0.063	0.006	0.126	−0.027	0.135	−0.008	0.098
Conv—ID2W 5 km	−0.086	0.050	0.006	0.137	−0.011	0.125	−0.002	0.103
Conv—Density 10 km	0.068	0.080	0.014	0.020	−0.094	0.123	−0.061	0.019
Conv—Density 5 km	0.072	0.036	0.014	0.049	−0.107	0.153✝	−0.144	−0.004
Acetone	0.032	0.085	0.017	0.071	−0.002	0.106	0.062	0.023
Chloroform	−0.159	−0.127	−0.147	−0.106	0.060	−0.017	−0.138	−0.143
1,4-Dioxane	−0.055	0.003	0.074	0.075	0.066	−0.209*	0.185	−0.078
Decanal	0.121	−0.059	0.150	0.078	−0.037	−0.037	−0.182	0.019
Hexanal	0.035	−0.101	0.015	−0.034	−0.249*	−0.049	−0.050	0.165✝
mp-Xylene	−0.028	0.003	−0.042	0.153	−0.095	0.048	0.021	−0.085
o-Xylene	−0.022	0.002	−0.040	0.148	−0.115	0.039	−0.007	−0.075
Styrene	−0.015	0.025	−0.045	0.057	−0.086	0.085	0.002	−0.102
BTEX	0.054	−0.004	0.062	−0.066	−0.014	0.113	−0.068	−0.097

Sample size = 85. Pooled urine samples run in duplicate for assays. Significance is indicated by P-value symbols (*P ≤ 0.05; ^✝P ≤ 0.10). Standardized betas were calculated using multiple linear regression models. TAC, SOD, GST, and CAT models were standardized for age, gestational week at the time of recruitment, smoking status, Indigenous status, and urinary creatinine. aMT6 models were adjusted for age, gestational week at the time of recruitment, smoking status, Indigenous status, urinary creatinine, and time of sample collection. MDA, 8-IP, and 8-OHdG models were adjusted for melatonin, age, gestational week at the time of recruitment, smoking status, Indigenous status and urinary creatinine.