TABLE 4.

Mediation analysis with mean choline intake as the mediator in the association of egg intake with Alzheimer’s dementia risk

Excess relative risk	Egg consumption
	Never or <1/mo	1–3/mo	1/wk	≥2/wk
Total effect	Reference	0.069 (–0.216, 0.353)	0.380 (-0.005, 0.765)	0.344 (0.005, 0.682)
		P = 0.636	P = 0.053	P = 0.047
Pure indirect effect	Reference	0.022 (–0.012, 0.056)	0.044 (–0.005, 0.093)	0.135 (0.025, 0.245)
		P = 0.202	P = 0.079	P = 0.016
Controlled direct effect	Reference	0.028 (–0.238, 0.293)	0.304 (–0.046, 0.654)	0.279 (0.071, 0.628)
		P = 0.839	P = 0.089	P = 0.118
Reference interaction	Reference	–0.001 (–0.007, 0.005)	–0.004 (–0.014, 0.005)	0.037 (–0.017, 0.091)
		P = 0.698	P = 0.384	P = 0.184
Mediated interaction	Reference	0.020 (–0.012, 0.056)	0.036 (–0.068, 0.141)	–0.107 (–0.252, 0.038)
		P = 0.389	P = 0.499	P = 0.147