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. 2005 Feb 22;386(Pt 2):221–226. doi: 10.1042/BJ20041973

Figure 4. Unlike SePP KO mice, liver-specific selenoprotein KO mice do not display a movement disorder.

Figure 4

(A) Rotarod analysis. No differences in motor co-ordination were observed between genotypes Trspfl/fl and Trspfl/+ (n=21), Alb-Cre; Trspfl/+ (n=12), and Alb-Cre; Trspfl/fl (n=15). (B) Footprint analysis. Stride length is compared between SePP KO mice, SePP KO mice rescued with selenite from birth (1 μM or 10 μM in drinking water) and liver-specific selenoprotein KO mice. Selenite supplementation dose-dependently leads to amelioration of the movement disorder of SePP KO mice, while liver-specific selenoprotein KO mice are indistinguishable from wild-type mice. Results from wild-type littermate controls of each group were similar. (n=4–6). Significance of differences: n.s. not significant; *P<0.05; ***P<0.001 (one-way ANOVA with Dunnett's post hoc test).