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. 2024 Aug 15;13(3):69. doi: 10.3390/antib13030069

Figure 3.

Figure 3

Response profile of IgG antibody subclasses (IgG1, IgG2, and IgG3) against PvCelTOS(I133-G147), PvTRAP(P344-G374) and PvCyRPA(T289-G307) in the acute (AC) and convalescent phases of P. vivax (Conv 30 and Conv 180). The dashed line represents the cut-off that separates responders from non-responders. The horizontal line in the scatter plots represents the median reactivity index (RI) value. Each sample was tested in duplicate by ELISA. Statistical significance of the frequency of responders (blue bars) at different points for each antigen was assessed using the chi-square test with Fischer’s post-test for multiple comparisons. Statistical significance of the RI (black bars) observed at different points for each antigen was assessed using the Kruskal–Wallis test with Mann–Whitney post-test for multiple comparisons (p < 0.05). Asterisks represent p value summary, * p < 0.05; ** p < 0.005; *** p < 0.0005. 30 (convalescent 30 days), 180 (convalescent 180 days). (A) PvCelTOS(I133-G147); acute: n = 27, Conv 30: n = 21, Conv 180: n = 12, CH: n = 12. (B) PvTRAP(P344-G374); acute: n = 31, Conv 30: n = 26, Conv 180: n = 11, CH: n = 11. (C) PvCyRPA(T289-G307); acute: n = 16, Conv 30: n = 12, Conv 180: n = 5, CH: n =7.