Table 2.
Colocalization of mQTLs of CpG sites and SNPs of cardiometabolic traits in the replication study.
Trait (Source) |
CpG Site | Lead SNP (A1 Allele) |
Association * | Colocalization Results | |||
---|---|---|---|---|---|---|---|
B | p | B | PSMR | PHEIDI | |||
Body fat percentage (UKBB) |
cg23627948 | rs798549(C) | 0.01 | 1.3 × 10−8 | 0.06 | 1.61 × 10−8 | 0.3 |
0.15 | <2 × 10−200 | ||||||
DBP (UKBB) |
cg21153102 | rs11070317(C) | 0.18 | 1.7 × 10−24 | 2.06 | 6.1 × 10−23 | 0.3 |
0.09 | 5.2 × 10−294 | ||||||
Kidney function (PMID: 31152163) |
cg05280698 | rs73025481(A) | 0.004 | 2.3 × 10−23 | 0.04 | 2.5 × 10−16 | 0.02 |
0.08 | 3.2 × 10−47 | ||||||
SBP (UKBB) |
cg03186999 | rs222851(A) | −0.27 | 8.6 × 10−19 | −11.22 | 4.3 × 10−14 | 0.03 |
0.02 | 1.7 × 10−47 |
* indicates the association of the lead SNP with the trait (first row) and the CpG site (second row).