Table 4.

The outcome of Mendelian randomization; nature of association between the identified CpG sites, genes, and cardiometabolic traits.

Predictor	Outcome	B	SE	p	NSNPs
cg23627948 → GNA12 → Obesity
cg23627948	Body fat percentage	0.01	0.001	1.0 × 10−8	17
cg23627948	GNA12	−0.10	0.007	4.4 × 10−47	7
GNA12	Body fat percentage	−0.03	0.004	4.5 × 10−12	20
cg21153102 → GCHFR/CHP1 → DBP
cg21153102	DBP	0.18	0.02	1.8 × 10−23	12
cg21153102	CHP1	−0.15	0.009	1.7 × 10−53	12
cg21153102	GCHFR	0.05	0.008	1.9 × 10−11	7
CHP1	DBP	−0.57	0.08	9.8 × 10−13	6
GCHFR	DBP	0.39	0.06	4.1 × 10−10	9
cg05280698 → HKR1 → Kidney function
cg05280698	Kidney Function	0.01	0.001	2.3 × 10−9	3
cg05280698	HKR1	−0.42	0.02	5.4 × 10−87	3
HKR1	Kidney Function	−0.01	0.001	5.1 × 10−11	17
cg03186999 → CTDNEP1 → SBP
cg03186999	SBP	−0.44	0.05	7.2 × 10−16	3
cg03186999	CTDNEP1	0.26	0.02	2.4 × 10−46	3
CTDNEP1	SBP	−1.05	0.1	1.0 × 10−19	5