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. 2024 Jul 4;11(32):2405084. doi: 10.1002/advs.202405084

Figure 6.

Figure 6

Cancer on a chip (CoC). Schematic of multi‐organ on chip (Multi‐OoC) for CRC modelling. By combining multi‐organ systems and 3D cell culture, this technology enables the connection of CRC cells and TME models with multiple organs and tissues in a closed‐loop system. Moreover, this platform offers a powerful tool for mimicking cancer metastasis (metastasis‐on‐a‐chip). For example, it integrates CRC cells with liver, lung, and endothelial cells to reproduce the tropism of CRC cells during spreading to distant organs. Adapted with permission.[ 125 ] Copyright 2018, Wiley Periodicals, Inc. Panel A) shows an example of a metastasis‐on‐a‐chip device consisting of a main microfluidic chamber seeded with CRC cells, connected to multiple downstream chambers in which endothelial (E), lung (Lu), liver (Li), and gel control constructs are housed B). Under recirculating fluid flow, the movement of cells can be tracked via fluorescent imaging (RFP+ cells) C) from the primary site to 4 downstream potential sites of metastasis, reproducing CRC cells spread and tropism for the liver and lungs. Adapted with permission.[ 125 ] Copyright 2018, Wiley Periodicals, Inc. Part of the figure is modified from Servier Medical Art (http://smart.servier.com/), licensed under a Creative Common Attribution 3.0 Generic License.