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Schematic illustration of using biomimetic nanovesicles to prevent HIRI by MMs with CLs. a) Construction of MMCLs by the extrusion method. b) MMCLs exhibited inflammation chemotaxis to the hepatic lesion site and escaped from macrophage clearance after tail intravenous injection. Hepatocyte uptake of MMCLs can release CsA to bind with CypD on the mitochondrial membrane, close the mPTP, alleviate mitochondrial dysfunction, and reduce cell apoptosis.
