AAT	Alpha-1 anti-trypsin
AATD	Alpha-1 anti-trypsin deficiency
AIM2	interferon-inducible protein
ALI	air–liquid interface
AMs	alveolar macrophages
Ant-21	miR-21-specific antagomir
ASM	airway smooth muscle
BAL	bronchoalveolar lavage
BALF	bronchoalveolar lavage fluid
CF	cystic fibrosis
CG	Cathespin-G
COPD	chronic obstructive pulmonary disease
CS	cigarette smoke
CT	computer tomography
DAMPs	damage-associated molecular patterns
ECM	extracellular matrix
FEV1	forced expiratory volume in one second
FVC	forced vital capacity
GM-CSF	granulocyte macrophage colony-stimulating factor
GOLD	global initiative for chronic obstructive lung disease
GTPase	guanosine triphosphatase
ICSs	inhaled corticosteroids
IFN-g	interferon-gamma
IL-13	interleukin 13
IL-22	interleukin 22
IL-4	interleukin 4
IPF	idiopathic pulmonary fibrosis
LABAs	long-acting beta-2 agonists
LAMAs	long-acting muscarinic agonists
LC-MS/MS	liquid chromatography with tandem mass spectrometry
LOXL2	lysyl oxidase-like 2
miR-21	MicroRNA-21
miR-328	MicroRNA 328
NE	neutrophil elastase
NK	natural killer
PKR	protein kinase R
PR3	proteinase-3
PRM	parametric response mapping
PTM	post-translational modification
QOL	quality of life
RHO	Ras homology family member
ROS	reactive oxygen species
SABA	short-acting beta-2 agonists
SAMA	short-acting muscarinic agonists
sRAGE	soluble receptor for advanced glycation end products
SSAO	semicarbazide-sensitive amine oxidase
TLR7	Toll-like receptor 7
TRAIL	tumor necrosis factor-related apoptosis-inducing ligand