In vitro cytotoxic activities of selected synthesized compounds against MCF-7, HepG2 and VERO cell lines and VEGFR-2 kinase assay.

Comp.	IC50a (μM)
	MCF-7	HepG2	VERO	VEGFR-2
3a	1.16 ± 0.01	1.27 ± 0.03	4.75 ± 0.31	1.25 ± 0.05
3b	0.83 ± 0.02	0.80 ± 01	4.25 ± 0.31	0.80 ± 0.05
3c	0.88 ± 0.03	1.25 ± 0.02	4.11 ± 0.43	0.84 ± 0.05
3d	0.74 ± 0.01	0.15 ± 01	4.35 ± 0.31	0.70 ± 0.05
3e	0.08 ± 0.01	0.19 ± 01	3.22 ± 0.31	0.12 ± 0.02
4a	0.16 ± 01	0.29 ± 0.01	4.00 ± 0.32	0.15 ± 0.03
4b	0.06 ± 0.01	0.06 ± 0.01	3.00 ± 0.31	0.09 ± 0.02
5a	0.86 ± 0.01	0.80 ± 0.02	4.12 ± 0.42	0.75 ± 0.05
5b	0.11 ± 0.01	0.15 ± 0.01	3.15 ± 0.31	0.13 ± 0.03
Sorafenib	0.05 ± 0.01	0.03 ± 0.01	NTb	0.022 ± 0.06

^aIC₅₀ values are the mean ± SD of three separate experiments.

^bNT = not tested.