Table 2.

Comparison of NGS With Culture-based Susceptibility Testing

	Culture	Gastric NGS	Stool NGS
Availabilitya	++	+	+
Genotypic-phenotypic correlation	NA	High for clarithromycin and levofloxacin Uncertain for metronidazole	High for clarithromycin and levofloxacin Uncertain for metronidazole
Technical success	Variable, 50%-80%	>90%	>90%
Repeat endoscopy for susceptibility testing	Yes	Yes	No

NA, not applicable; NGS, next-generation sequencing.

^a ++, available in several US laboratories; +, only available currently from a single US laboratory.