Fig. 1.

BET inhibitors/-degraders change the protein expression and induce cell death in DLBCL. a) Induction of cell death [%] after 24 h treatment with the indicated BET inhibitors/-degraders at 1µM measured by AnnexinV-FITC/PI staining and flow cytometry [data are shown as mean + standard deviation (SD) with n = 3]. b-d) Western Blot of BRD4, c-MYC and BCL2-familiy proteins after 24 h treatment with the indicated BET inhibitors/-degraders at 1µM in b) SUDHL2, c) TMD8 and d) U2932 cells with GAPDH serving as housekeeping control [one representative blot out of three independent experiments is shown]