Table 4.
Factor associated with clustering and high linkages of newly diagnosed HIV-1 patients in Shaoxing from 2019 to 2023
| Categories | Cluster cases(%) (n = 398) | Univariate analysis | Multivariate analysis | High-risk cases(%) (n = 157) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | AOR (95% CI) | P | OR (95% CI) | P | AOR (95% CI) | P | |||
| Age(years) | ||||||||||
| < 50 | 199(50.0) | 1.000 | 1.000 | 44(28.0) | 1.000 | 1.000 | ||||
| ≥ 50 | 199(50.0) | 2.386(1.821–3.127) | 0.000 | 1.868(1.329–2.625) | 0.000 | 113(72.0) | 4.629(2.991–7.164) | 0.000 | 5.149(2.689–9.859) | 0.000 |
| Sex | ||||||||||
| Male | 313(78.6) | 1.000 | 1.000 | 123(78.3) | 1.000 | |||||
| Female | 85(21.4) | 1.500(1.072–2.099) | 0.018 | 1.282(0.867–1.896) | 0.213 | 34(21.7) | 1.030(0.631–1.680) | 0.906 | ||
| Ethnicity | ||||||||||
| Ethnic Han | 398(96.7) | 1.000 | 1.000 | 154(98.1) | 1.000 | |||||
| Others | 13(3.3) | 0.442(0.232–0.841) | 0.013 | 0.464(0.232–0.925) | 0.029 | 3(1.9) | 0.450(0.122–1.661) | 0.231 | ||
| Married status | ||||||||||
| Single | 100(25.1) | 1.000 | 1.000 | 25(15.9) | 1.000 | 1.000 | ||||
| Married | 237(59.5) | 1.734(1.284–2.340) | 0.000 | 1.083(0.750–1.563) | 0.671 | 101(64.3) | 2.228(1.324–3.750) | 0.003 | 0.573(0.264–1.245) | 0.160 |
| Divorced/Widowed | 58(14.6) | 1.253(0.831–1.891) | 0.282 | 0.803(0.507–1.273) | 0.351 | 30(19.1) | 3.214(1.619–6.381) | 0.001 | 1.533(0.646–3.639) | 0.333 |
| Unknow | 3(0.8) | 1.880(0.373–9.486) | 0.445 | 1.095(0.176–6.830) | 0.922 | 1(0.6) | 1.500(0.130–17.257) | 0.745 | 0.076(0.004–1.288) | 0.074 |
| Education | ||||||||||
| Junior college or above | 51(12.8) | 1.000 | 1.000 | 11(7.0) | 1.000 | 1.000 | ||||
| High or technical secondary school | 82(20.6) | 0.152(1.004–2.399) | 0.048 | 1.439(0.914–2.265) | 0.117 | 24(15.3) | 1.505(0.663–3.415) | 0.328 | 1.407(0.547–3.617) | 0.478 |
| Junior middle school | 138(34.7) | 1.712(1.149–2.552) | 0.008 | 1.281(0.829–1.981) | 0.265 | 57(36.3) | 2.559(1.211–5.408) | 0.014 | 1.510(0.611–3.733) | 0.372 |
| Primary school/illiterate | 127(31.9) | 2.145(1.422–3.238) | 0.000 | 1.331(0.819–2.164) | 0.249 | 65(41.4) | 3.812(1.796–8.091) | 0.000 | 1.528(0.604–3.866) | 0.371 |
| Household registered | ||||||||||
| Other provinces | 32(8.0) | 1.000 | 1.000 | 15(9.6) | 1.000 | 0.231 | ||||
| Other cities in Zhejiang | 15(3.8) | 0.811(0.389–1.691) | 0.576 | 0.702(0.325–1.517) | 0.368 | 3(1.9) | 0.283(0.067–1.200) | 0.087 | ||
| Shaoxing city | 351(88.2) | 1.618(1.034–2.529) | 0.035 | 1.481(0.923–2.376) | 0.103 | 139(88.5) | 0.746(0.359–1.537) | 0.423 | ||
| Subtype | ||||||||||
| CRF07_BC | 204(51.3) | 1.000 | 1.000 | 101(64.3) | 1.000 | 1.000 | ||||
| CRF01_AE | 89(22.4) | 0.578(0.422–0.791) | 0.001 | 0.678(0.487–0.944) | 0.021 | 18(11.5) | 0.259(0.144–0.464) | 0.000 | 0.303(0.148–0.622) | 0.001 |
| Other | 105(26.4) | 1.201(0.865–1.667) | 0.274 | 1.185(0.829–1.683) | 0.353 | 38(24.2) | 0.578(0.357–0.938) | 0.026 | 0.410(0.214–0.786) | 0.007 |
| Sexual contact | ||||||||||
| Heterosexual | 270(67.8) | 1.000 | 1.000 | 125(79.6) | 1.000 | 1.000 | ||||
| Homosexual | 121(30.4) | 0.634(0.481–0.836) | 0.001 | 1.053(0.744–1.489) | 0.771 | 25(15.9) | 0.302(0.183–0.498) | 0.000 | 0.494(0.244–0.999) | 0.050 |
| Unknow | 7(1.8) | 0.724(0.277–1.893) | 0.510 | 0.632(0.222–1.799) | 0.390 | 7(4.5) | / | |||
| PDR | ||||||||||
| No | 313(78.6) | 1.000 | 1.000 | 95(60.5) | 1.000 | 1.000 | ||||
| Yes | 85(21.4) | 2.577(1.771–3.750) | 0.000 | 2.219(1.491–3.301) | 0.000 | 62(39.5) | 6.186(3.620–10.570) | 0.000 | 3.899(1.971–7.711) | 0.000 |
| Current place of residence | ||||||||||
| Yuecheng | 127(31.9) | 1.000 | 67(42.7) | 1.000 | 1.000 | |||||
| Keqiao | 113(28.4) | 1.521(0.767–3.018) | 0.230 | 48(30.6) | 0.661(0.397–1.102) | 0.112 | 1.232(0.654–2.320) | 0.519 | ||
| Zhuji | 84(21.1) | 1.169(0.589–2.317) | 0.656 | 25(15.9) | 0.379(0.212–0.680) | 0.001 | 0.822(0.401–1.686) | 0.593 | ||
| Shangyu | 22(5.5) | 0.833(0.417–1.664) | 0.604 | 3(1.9) | 0.141(0.040–0.502) | 0.002 | 0.469(0.112–1.967) | 0.301 | ||
| Shengzhou | 36(9.0) | 0.518(0.232–1.157) | 0.109 | 13(8.3) | 0.506(0.236–1.087) | 0.081 | 1.528(0.599–3.900) | 0.375 | ||
| Xingchang | 16(4.0) | 1.101(0.509–2.382) | 0.807 | 1(0.6) | 0.060(0.008–0.466) | 0.007 | 0.121(0.014–1.073) | 0.058 | ||
Others genotypes were CRF08_BC, CRF85_BC,CRF55_01B,B,C,CRF87_cpx,CRF57_BC,02_AG、URF(B/C)、URF(CRF01_AE/_B) and URF(CRF01_AE/CRF07_BC); PDR: pretreatment drug resistance; OR: odds ratio;AOR: adjusted odds ratio; red data represent P ≤ 0.05