Table 3.
Pathways identified for incident CVD groups
| CVD group | Hierarchical group | Gene set name | # Genes in Gene Set (K) | # Genes in Overlap (k) | k/K | P value | FDR q value |
|---|---|---|---|---|---|---|---|
| Arterial and other cardiovascular diseases | Metabolism of proteins |
Posttranslational protein modification (R-HSA-597592) |
1442 | 30 | 0.0208 | 2.46E−7 | 4.52E−4 |
| Gene expression (Transcription) |
RNA Polymerase II Transcription (R-HSA-73857) |
1393 | 28 | 0.0201 | 1.23E−6 | 1.14E−3 | |
| Metabolism of RNA |
Metabolism of RNA (R-HSA-8953854) |
714 | 17 | 0.0238 | 2.03E−5 | 1.25E−2 | |
| Chromatin organization |
Chromatin modifying enzymes (R-HSA-3247509) |
274 | 10 | 0.0365 | 3.39E−5 | 1.56E−2 | |
| Diseases of the veins and lymphatic system | Cell–Cell communication |
Tight junction interactions (R-HSA-420029) |
30 | 3 | 0.1000 | 3.58E−6 | 6.58E−3 |
| Cell–Cell communication |
Cell–cell junction organization (R-HSA-421270) |
65 | 3 | 0.0462 | 3.76E−5 | 3.46E−2 |
Arterial and other cardiovascular diseases (ICD-8: 420–429,440–448 + ICD-10: I27–I28, I30–I52, I70–I79), diseases of the veins and lymphatic system (ICD-8: 450–457 + ICD-10: I26, I80, I89), FDR: false discovery rate