Fig. 5.

Antitumor activity of AZD5305 as single agent and in combination with other DNA damaging agents. Waterfall plots showing the antitumor activity of AZD5305 with A carboplatin as single agent and in combination in n = 6 PDX models and with B AZD6738 as single agent and in combination in n = 5 models, measured as percentage of tumor volume change, compared with the tumor volume on day 1. Each bar indicates the mean and SEM of at least three biological replicates (open circles). The mean of control tumors (n ≥ 3) is represented with solid circles. + 20%, − 30%, and − 95% are marked by dotted lines to indicate the range of PD, SD, PR, and CR, respectively. The lower box summarizes the RAD51 score (%), the specific gene alteration harbored by each model, the cancer type, and previous treatment history with DDR drugs in the "Early"-stage vs. "Metastatic" disease setting. Rev, reversion mutation; DDR, DNA damage repair. p values, pairwise Wilcoxon test corrected for multiple testing