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. Author manuscript; available in PMC: 2024 Aug 27.
Published in final edited form as: Cell Rep. 2024 Apr 21;43(5):114127. doi: 10.1016/j.celrep.2024.114127

Figure 3. Disease phenotypes and identification of a severe EVD-like disease QTL on chr7.

Figure 3.

Eight- to 10-week-old CC011xCC074-F2 mice (n = 236; 123 females, 113 males) were generated and infected with 100 ffu MA-EBOV i.p. and followed for 6 days for weight loss and mortality.

(A) Weight loss on day 5 post infection of CC011xCC074-F2 mice.

(B) Survival of CC011xCC074-F2 mice over the time of infection.

(C) QTL map for the weight loss on day 5 post infection.

(D) QTL map for the overall survival rate over the time of infection. Phenotypes were grouped based on a homozygous CC011 genotype, a heterozygous genotype, and a homozygous CC074 genotype. (E) The allele plot for weight loss on 5 dpi, and (F) the allele plot for percentage survival over the time of infection; 0 = alive, 1 = dead. Data were analyzed using Mann-Whitney test (allele plots for weight loss and survival). LOD, log10 likelihood ratio; dotted line indicates the genome-wide p = 0.05 significance threshold.