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. Author manuscript; available in PMC: 2024 Aug 27.
Published in final edited form as: Cell Rep. 2024 Apr 21;43(5):114127. doi: 10.1016/j.celrep.2024.114127

Figure 6. Differentially expressed gene signatures in the liver in Trim+/+ and Trim/ mice.

Figure 6.

(A) Heatmap of the top five ranked genes in the top 10 significantly enriched pathways in infected Trim+/+ and Trim/ mice compared to their respective mock-infected controls (<1.5 log2 fold over mock; p < 0.05); shown are the average expression levels for each gene for each group on 6 dpi (n = 5 females for all time points, n = 3 females for all time points for mocks).

(B) Heatmap of key genes being significantly affected during the development of EVD-like disease in the liver (in bold). For each gene, the average normalized transcript counts (log2 cpm.) are shown. Data were analyzed using Mann-Whitney test; significance is indicated as p* < 0.05, **p < 0.005 (n = 5 EBOV-infected females for all time points, n = 3 mock-infected females for all time points).