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. 2013 Oct 2;2013(10):CD003564. doi: 10.1002/14651858.CD003564.pub3

Comparison 1. Beta2‐agonists versus placebo (single administration).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Maximal percentage fall in FEV1 72 799 Mean Difference (Random, 95% CI) ‐17.67 [‐19.51, ‐15.84]
2 Number of participants with an FEV1 fall > 10% 19 773 Odds Ratio (M‐H, Random, 95% CI) 0.08 [0.06, 0.13]
3 Number of participants with an FEV1 fall > 15% 13 457 Odds Ratio (M‐H, Random, 95% CI) 0.06 [0.03, 0.15]
4 Number of participants with an FEV1 fall > 20% 25 1021 Odds Ratio (M‐H, Random, 95% CI) 0.09 [0.06, 0.14]
5 Maximal percentage fall in PEF 14 92 Mean Difference (Random, 95% CI) ‐24.61 [‐37.57, ‐11.65]
6 Maximal percentage fall in FEF 25‐75 8 106 Mean Difference (Fixed, 95% CI) ‐20.75 [‐27.17, ‐14.32]
7 Side effects 55 2165 Odds Ratio (M‐H, Random, 95% CI) 0.83 [0.43, 1.59]
8 Subgroup analysis: maximal percentage fall in FEV1 SABA vs LABA 72   Mean Difference (Random, 95% CI) ‐17.67 [‐19.51, ‐15.84]
8.1 SABA 44   Mean Difference (Random, 95% CI) ‐18.99 [‐21.38, ‐16.60]
8.2 LABA 28   Mean Difference (Random, 95% CI) ‐15.60 [‐18.29, ‐12.92]
9 Subgroup analysis: maximal percentage fall in FEV1: salmeterol versus formoterol 28   Mean Difference (Random, 95% CI) ‐15.60 [‐18.29, ‐12.92]
9.1 Salmeterol 13   Mean Difference (Random, 95% CI) ‐12.73 [‐16.10, ‐9.37]
9.2 Formoterol 15   Mean Difference (Random, 95% CI) ‐18.24 [‐22.15, ‐14.34]
10 Subgroup analysis: maximal percentage fall in FEV1: adults versus children 51   Mean Difference (Random, 95% CI) ‐16.75 [‐19.12, ‐14.39]
10.1 Adults 19   Mean Difference (Random, 95% CI) ‐18.77 [‐20.78, ‐16.76]
10.2 Children 32   Mean Difference (Random, 95% CI) ‐15.32 [‐18.88, ‐11.75]