Carlsen 1995 Salm 25.

Methods	Study design: Randomized, double blind, cross over Study location: Norway Wash‐out: 2‐14 days Exercise challenge: Treadmill for 6 min up to 170‐180 bpm Criteria for EIB diagnosis: Positive history, FEV1 fall >15% after exercise challenge
Participants	Number of subjects: 23 % of males: 47% Age range: 8‐16 years Ethnicity: Not reported Withdrawal or drop out: 0
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: between 10‐12 hours Intervention: Salmeterol diskhaler 25 mcg, Salmeterol diskhaler 50 mcg Control: Placebo Other drug arms: None Concomitant inhaled corticosteroid (ICS) treatment: Allowed
Outcomes	Primary available: Max FEV1 % fall; % protection Secondary available: Number of patients with a max FEV1 % fall <15%; Max MEF25‐50 % fall
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization described explicitly
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information