Cavagni 1993 Salb Jet.

Methods	Study design: Randomized, double blind, cross over Study location: Italy Wash‐out: Not reported Exercise challenge: Treadmill for 6 min up to 170‐180 bpm Criteria for EIB diagnosis: Positive history, FEV1 fall >15% after exercise challenge, FEV1 >15% after bronchodilator
Participants	Number of subjects: 9 % of males: 66% Age range: 5‐9 years Ethnicity: Not reported Withdrawal or drop out: 1
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: 10 min. Intervention: Salbutamol MDI 200 mcg, Salbutamol jet disposable 200 mcg Control: Placebo Other drug arms: None Concomitant inhaled corticosteroid (ICS) treatment: Not reported
Outcomes	Primary available: Max FEV1 % fall; % protection Secondary available: Side effects; Max PEF % fall; Max FEF25‐75 % fall
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information