Konig 1984 Fen 0.4.

Methods	Study design: Randomized, double blind, cross over Study location: United States Wash‐out: Not reported Exercise challenge: Treadmill up to 90% of max HR Criteria for EIB diagnosis: Asthma according to ATS; FEV1 fall >20% after exercise challenge
Participants	Number of subjects: 12 % of males: 100% Age range: 17‐29 years Ethnicity: Not reported Withdrawal or drop out: 0
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: 10 min, 2 hours, 4 hours Intervention: Fenoterol 40 mcg; Fenoterol 80 mcg Control: Placebo Other drug arms: No Concomitant inhaled corticosteroid (ICS) treatment: Allowed
Outcomes	Primary available: Max FEV1 % fall; % protection Secondary available: Max FEF 25‐‐75 % fall; Side effects; Number of patients with a max FEV1 % fall <10%;
Notes	Industry funded study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	High risk	Data for max FEF 25‐‐75 % fall not reported
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information