Larsson 1982 Fen.

Methods	Study design: Randomized, double blind, cross over Study location: Sweden Wash‐out: Not reported Exercise challenge: Cycle ergometer for 6‐9 min till exhaustion Criteria for EIB diagnosis: FEV1 fall >15% after exercise challenge
Participants	Number of subjects: 8 % of males: 69% Age range: 29‐64 years Ethnicity: Not reported Withdrawal or drop out: 0
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: 10 min Intervention: Fenoterol 400 mcg Control: Placebo Other drug arms: Oxitropium bromide; Ipratropium bromide Concomitant inhaled corticosteroid (ICS) treatment: Any anti‐asthmatic drug suspended 12 hours before the test
Outcomes	Primary available: Max FEV1 % fall; % protection Secondary available: Number of patients with a max FEV1 % fall <15%;
Notes	Industry funded study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information