McFadden 1986 Salb (II).

Methods	Study design: Randomized, double blind, cross over Study location: United States Wash‐out: 1‐10 days Exercise challenge: Cycle ergometer for 4‐5 min till exhaustion Criteria for EIB diagnosis: Positive screening exercise challenge
Participants	Number of subjects: 20 % of males: 60% Age range: Not reported Ethnicity: Not reported Withdrawal or drop out: 0
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: 15 min Intervention: Salbutamol 180 mcg Control: Placebo Other drug arms: No Concomitant inhaled corticosteroid (ICS) treatment: Not allowed
Outcomes	Primary available: Max FEV1 % fall; % protection Secondary available: Max FEF 25‐‐75 % fall; Side effects; Number of patients with a max FEV1 % fall <20%;
Notes	Industry funded study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information