Pearlman 2007 Salb 90.

Methods	Study design: Randomized, double blind, cross over Study location: United States Wash‐out: 3‐7 days Exercise challenge: Treadmill for at least 4 min at 85% of max HR Criteria for EIB diagnosis: Exercise‐induced bronchoconstriction for at least 6 months; FEV1 fall >20% and <50% after exercise challenge
Participants	Number of subjects:15 % of males: 86% Age range: Not reported Ethnicity: 100% Caucasian Withdrawal or drop out: 0
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: 20 min Intervention: Salbutamol 90 mcg Control: Placebo Other drug arms: No Concomitant inhaled corticosteroid (ICS) treatment: Allowed
Outcomes	Primary available: Max FEV1 % fall; % protection; FEV1 % fall AUC Secondary available: Side effects; Number of patients with a max FEV1 % fall <10%, <15% and <20%
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization described explicitly
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information