Simons 1997.

Methods	Study design: Randomized, double blind, cross over Study location: Canada Wash‐out: 14 days Exercise challenge: Treadmill for 8 min up to 90% of max HR or 180 bpm Criteria for EIB diagnosis: Asthma according to ATS; Positive exercise challenge
Participants	Number of subjects: 16 % of males: 41% Age range: 12‐16 years Ethnicity: Not reported Withdrawal or drop out: 2
Interventions	Drug administration: Chronic administration (28 weeks) Time of exercise challenge after drug administration: 1 hour, 9 hours Intervention: Salmeterol 50 mcg Control: Placebo Other drug arms: None Concomitant inhaled corticosteroid (ICS) treatment: Allowed
Outcomes	Primary available: Max FEV1 % fall; % protection; FEV1 % fall AUC Secondary available: None
Notes	Industry funded study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization described explicitly
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information