Vasquez 1984 Salb 400.

Methods	Study design: Randomized, double blind, parallel groups Study location: Spain Wash‐out: Not applicable Exercise challenge: Free running 5‐8 min at max speed (around 170 bpm) Criteria for EIB diagnosis: FEV1 fall >15% after exercise challenge
Participants	Number of subjects: 25 % of males: Not reported Age range: Not reported Ethnicity: Not reported Withdrawal or drop out: 0
Interventions	Drug administration: Single dose Time of exercise challenge after drug administration: 15 min. Intervention: Salbutamol 400 mcg Control: Placebo Other drug arms: Disodium cromoglycate 200 mcg; Ipratropium bromide 40 mcg; Concomitant inhaled corticosteroid (ICS) treatment: Not reported
Outcomes	Primary available: Max FEV1 % fall; % protection; Secondary available: Number of patients with a max FEV1 % fall <15%; Max MEF50 % fall;
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information