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. Author manuscript; available in PMC: 2024 Aug 27.
Published in final edited form as: Nat Genet. 2023 Nov 30;55(12):2235–2242. doi: 10.1038/s41588-023-01562-0

Fig. 5 |. TFBS are prone to high mutation rate.

Fig. 5 |

a, Box plot for the observed to expected rate of rare T > G mutations across different TFs. Positions occupied with TF were annotated with ChIP–seq data. Human tissues where TFBS are active were determined through overlap with tissue-specific DHS peaks. nuc. stands for nucleotides. Median is shown by a middle line, and box corresponds to 25–75% interval. b, Mutagenic effect of TFBS active in testis overlapping promoter (−2 KB upstream of transcription start site, dark yellow) or not (light yellow).