Extended Data Fig. 2 |. Roulette captures mutation rate variation associated with epigenetic features.

Ten pairs of mutation type and epigenetic features with the strongest effects on mutation rate. To generate bins, we subdivided the genome into five equal size bins by the value of genomic features and then calculated observed and expected mutation rates for each trinucleotide context among synonymous sites. This test was performed on synonymous SNVs and mutation rates were normalized to the rate observed in the first epigenetic bin. RT stands for replication timing. Overall, we analyzed the effect of replication timing, H3k27me3, H3k27me1 and recombination.