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. Author manuscript; available in PMC: 2024 Aug 27.
Published in final edited form as: Nat Neurosci. 2023 Nov 2;26(11):1929–1941. doi: 10.1038/s41593-023-01462-w

Extended Data Fig. 5: Effects of PC-PBN and PC-DCN suppression on motor behaviors.

Extended Data Fig. 5:

a-c. Halo/PCP-cre and wildtype control mice with bilateral optical fiber implants targeting their PBN or DCN were subcutaneously implanted with wires in their backs to measure a field EMG (n = 5). Mice were head restrained over a freely moving wheel. Speed of the wheel (top) and field EMG (bottom) during stimulation (10 Hz, 5 s), were measured (n = 5). (PBN implant EMG/Wheel n=5/5, DCN implant EMG/Wheel n = 4/7, control animals EMG/Wheel n=5/5).

d-f. Mice in those groups were also tested in the open field, where 10 Hz optical stimuli were delivered in 60 s intervals. Average position heat maps are shown for each interval (stimulus on and stimulus off).

B. Fraction of time in center and average velocity during the open field for the total duration of the test and for the durations while the stimulus was off and on for wildtype control animals.

C. As in g, but for PCP2cre/Halo animals implanted in the PBN.

B. As in h, but for PCP2cre/Halo animals implanted in the DCN.

* p<0.05, see Table 4