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. 2024 Jun 7;50(5):1255–1265. doi: 10.1093/schbul/sbae087

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Conditional quantile-quantile (Q-Q) plots and Mendelian randomization scatter plots for the associations between schizophrenia (SCZ) and anorexia nervosa (AN). The conditional quantile-quantile plot of nominal vs empirical −log₁₀ p values for SCZ as a function of significant association with AN at P value <.1, P value <.01, and P value <.001 (A), and vice versa (B). The black diagonal line indicates the global null hypothesis. Scatter plots for effects of SCZ and AN for instrumental variants of SCZ (panel C, n = 127), and AN (panel D, n = 18). Lines represent the regression of SNP effects for exposure (SCZ for A and AN for B) on the SNP effects for outcome (AN for A and SCZ for B), corresponding to a meta-analysis using random-effects inverse variance weighted, MR-Egger regression, weighted-mode, and weighted-median methods. Note: MR, Mendelian randomization.