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. 2024 Jun 7;50(5):1255–1265. doi: 10.1093/schbul/sbae087

Table 1.

Genomic Loci Jointly Associated With Schizophrenia and Anorexia Nervosa at conjFDR <0.05a,*,

Locus Chr Lead SNP A1 A2 Nearest Gene Functional Category CADD RDB min ChrState BETA for SCZ P Value for SCZ BETA for AN P Value for AN ConjFDR
1 1 rs12049457 A G NEGR1 Intronic 1.756 5 2 0.042 1.78 × 10−6 0.058 3.29 × 10−5 0.049
2 1 rs77663034 C T RPL7P9 Intergenic 4.164 5 7 −0.061 1.63 × 10−4 −0.113 9.78 × 10−6 0.046
3 3 rs9878063 T G CELSR3 Intronic 13.260 4 4 −0.062 5.00 × 10−6 −0.135 8.77 × 10−11 0.011
4 6 rs2388334 A G RP11-436D23.1 ncRNA_intronic 5.756 7 5 −0.032 1.80 × 10−4 −0.056 2.82 × 10−5 0.048
5 7 rs10254364 G A RELN Intergenic 2.652 6 5 −0.033 1.12 × 10−4 −0.065 1.98 × 10−6 0.041
6 8 rs4129585 A C TSNARE1 Intronic 6.646 / 5 0.075 5.11 × 10−18 0.0593 9.42 × 10−6 0.023
7 9 rs11795350 A G RP11-315I14.5 Intergenic 2.079 7 4 0.092 1.75 × 10−6 0.131 2.52 × 10−5 0.045
8 11 rs4144893 G A NCAM1 Intronic 1.115 7 5 −0.051 3.46 × 10−6 −0.078 4.06 × 10−6 0.013
9 12 rs4554988 G A SOX5 Intergenic 8.800 7 5 −0.038 1.09 × 10−5 −0.067 1.36 × 10−6 0.016
10 13 rs9546027 T A PTMAP5 Intergenic 2.057 7 9 0.035 1.05 × 10−4 0.062 2.31 × 10−5 0.043

aA1, allele 1; A2, allele 2; CADD, combined annotation-dependent depletion score; Chr, chromosome; ConjFDR, conjunctional false discovery rate; minChrState, minimum chromatin state; ncRNA, noncoding RNA; RDB, RegulomeDB score; UTR, untranslated region.

*The effect sizes are provided with A2 as the reference allele.