Table 1.
Locus | Chr | Lead SNP | A1 | A2 | Nearest Gene | Functional Category | CADD | RDB | min ChrState | BETA for SCZ | P Value for SCZ | BETA for AN | P Value for AN | ConjFDR |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | rs12049457 | A | G | NEGR1 | Intronic | 1.756 | 5 | 2 | 0.042 | 1.78 × 10−6 | 0.058 | 3.29 × 10−5 | 0.049 |
2 | 1 | rs77663034 | C | T | RPL7P9 | Intergenic | 4.164 | 5 | 7 | −0.061 | 1.63 × 10−4 | −0.113 | 9.78 × 10−6 | 0.046 |
3 | 3 | rs9878063 | T | G | CELSR3 | Intronic | 13.260 | 4 | 4 | −0.062 | 5.00 × 10−6 | −0.135 | 8.77 × 10−11 | 0.011 |
4 | 6 | rs2388334 | A | G | RP11-436D23.1 | ncRNA_intronic | 5.756 | 7 | 5 | −0.032 | 1.80 × 10−4 | −0.056 | 2.82 × 10−5 | 0.048 |
5 | 7 | rs10254364 | G | A | RELN | Intergenic | 2.652 | 6 | 5 | −0.033 | 1.12 × 10−4 | −0.065 | 1.98 × 10−6 | 0.041 |
6 | 8 | rs4129585 | A | C | TSNARE1 | Intronic | 6.646 | / | 5 | 0.075 | 5.11 × 10−18 | 0.0593 | 9.42 × 10−6 | 0.023 |
7 | 9 | rs11795350 | A | G | RP11-315I14.5 | Intergenic | 2.079 | 7 | 4 | 0.092 | 1.75 × 10−6 | 0.131 | 2.52 × 10−5 | 0.045 |
8 | 11 | rs4144893 | G | A | NCAM1 | Intronic | 1.115 | 7 | 5 | −0.051 | 3.46 × 10−6 | −0.078 | 4.06 × 10−6 | 0.013 |
9 | 12 | rs4554988 | G | A | SOX5 | Intergenic | 8.800 | 7 | 5 | −0.038 | 1.09 × 10−5 | −0.067 | 1.36 × 10−6 | 0.016 |
10 | 13 | rs9546027 | T | A | PTMAP5 | Intergenic | 2.057 | 7 | 9 | 0.035 | 1.05 × 10−4 | 0.062 | 2.31 × 10−5 | 0.043 |
aA1, allele 1; A2, allele 2; CADD, combined annotation-dependent depletion score; Chr, chromosome; ConjFDR, conjunctional false discovery rate; minChrState, minimum chromatin state; ncRNA, noncoding RNA; RDB, RegulomeDB score; UTR, untranslated region.
*The effect sizes are provided with A2 as the reference allele.