Table 2. Prevalence of Genetic DCM Within the Pediatric DCM Population by Region.
| Group | Number of studies | Weighted mean prevalence (SD)a | Total N | References |
|---|---|---|---|---|
| Overall genetic DCM | ||||
| Global | 9 | 21.3% (10.6) | 695 | [33, 34, 42, 54, 67, 71-74] |
| USA only | 3 | 17.3% (4.9) | 342 | [34, 73, 74] |
| TTN-associated DCM | ||||
| Global | 4 | 4.4% (5.1) | 450 | [34, 42, 71, 75] |
| USA only | 1 | 1.0% | 286 | [34] |
| MYH7-associated DCM | ||||
| Global | 5 | 5.7% (4.2) | 453 | [33, 34, 42, 72, 73] |
| USA only | 2 | 4.5% [34]; 11.1% [73] | 295 | [34, 73] |
aWeighted mean prevalence and weighted standard deviation were reported unless fewer than three studies were included in the calculation, in which case individual study prevalence estimates were presented. DCM: dilated cardiomyopathy; USA: United States of America; SD: weighted standard deviation.