Table 3. Prevalence of DCM-Associated Genetic Variants in Healthy Individuals by Region.
| Group | Number of studies | Weighted mean (SD)a | Total Nb | References |
|---|---|---|---|---|
| Overall genetic variants | ||||
| Global | 2 | 38.4% [60]; 2.7% [50] | 503 [60]; 445 [50] | [50, 60] |
| USA only | - | - | - | - |
| TTN variants | ||||
| Global | 6 | 0.9% (0.2) | 61,030 | [12, 21, 24, 25, 50, 60] |
| USA only | 1 | Healthy individuals: 2.9%; Women’s Health Initiative: 0.7% | Healthy individuals: 308; Women’s Health Initiative: 667 | [21] |
| MYH7 variants | ||||
| Global | 2 | 1.4% [25]; 1.4% [24] | 912 [25]; 60,471 [24] | [24, 25] |
| USA only | - | - | - | - |
aWeighted mean prevalence and weighted standard deviation were reported unless fewer than three studies were included in the calculation, in which case individual study prevalence estimates were presented. bTotal sample size was presented unless fewer than three studies were included in the calculation, in which case the individual studies’ samples sizes were presented. DCM: dilated cardiomyopathy; USA: United States of America; SD: weighted standard deviation.