Synaptic latency (SL) and network communication
speed. (A–C)
Time series of partial spikes in a burst of neurons before, during,
and after electrical stimulation (ES). (D–F) Scatter plot of
network distance to all firing sites from the first firing site depending
on network communication time before, during, and after electrical
stimulation. The dotted line and shaded area represent the best fit
of linear regression and the 95% confidence level, respectively. The
slope of the linear regression denotes the network communication velocity.
(G) Bar graph displaying the network communication velocity across
the before, during, and after electrical stimulation states, n = 5, *p < 0.05, *** p < 0.001. Note, data distribution is included in Figure S10-2. (H) Box-plots illustrating changes in synaptic
latency (SL) across days in vitro, n = 3, *** p < 0.001. Note, data distribution
is included in Figure S11-2. (I) Plot depicting
the communication connectivity mode across days in vitro.